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KMID : 0370220030470030130
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Yakhak Hoeji
2003 Volume.47 No. 3 p.130 ~ p.134
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Synthesis of N-Aryl Phenylglycine O-Alkyl Esters Using Hydrolysis of 1,5-Diphenylhydantoins
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박해선/Park HS
최희전/권순경/박명숙/Choi HJ/Kwon SK/Park MS
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Abstract
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For the development of new synthetic method for unnatural amino acid esters, N- aryl phenylglycine O-alkyl esters 4a~I were synthesized through base-catalyzed hyd rolysis of 1,5-diphenylhydantoins 1a~b and O-alkylation in 16~87% yield. An efficient and practical route for final 4a~I was that the starting materials 1a~b were heated in dil-meth-anol for 30 minute using sodium hydroxide or potassium hydroxide and evaporated. In addition, reaction mixture were refluxed for 1 h in DMF. All synthetic process from hydantoin to N-aryl phenylglycine O-alkyl esters 4a~1 could be carried out in one-pot without isolation of intermediates.
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KEYWORD
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